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The Product Types Ontology: Class Definition for "Antibody"

This page is part of http://www.productontology.org/, a huge, precise dictionary of product types and brand names for marking up Web sites with schema.org or the GoodRelations e-commerce standard.

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On this page: Usage(schema.org/Microdata, RDFa, Facebook) Contact Information Caching Policy License Acknowledgments References

pto:Antibody (rdf:type owl:Class)

URI http://www.productontology.org/id/Antibody
rdfs:subClassOf gr:ProductOrService, http://schema.org/Product
rdfs:label Antibody (as a class or brand name of products of services)
Translation(s):  Antikörper@als;  ኣንቲቦዲ@am;  جسم مضاد@ar;  প্ৰতিদেহ@as;  Antitel@az;  Антыцелы@be;  Антитяло@bg;  प्रतीदेह@bh;  অ্যান্টিবডি@bn;  Antitijelo@bs; 

rdfs:comment

An antibody (Ab) is the secreted form of a B cell receptor; the term immunoglobulin can refer to either the membrane-bound form or the secreted form of the B cell receptor, but they are, broadly speaking, the same protein, and so the terms are often treated as synonymous. Antibodies are large, Y-shaped proteins belonging to the immunoglobulin superfamily which are used by the immune system to identify and neutralize foreign objects such as bacteria and viruses, including those that cause disease. Antibodies can recognize virtually any size antigen with diverse chemical compositions from molecules. Each antibody recognizes one or more specific antigens. This term literally means "antibody generator", as it is the presence of an antigen that drives the formation of an antigen-specific antibody. Each tip of the "Y" of an antibody contains a paratope that specifically binds to one particular epitope on an antigen, allowing the two molecules to bind together with precision. Using this mechanism, antibodies can effectively "tag" a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. The rest of the antibody structure is relatively generic. In humans, antibodies occur in five classes, sometimes called isotypes: IgA, IgD, IgE, IgG, and IgM. Human IgG and IgA antibodies are also divided into discrete subclasses (IgG1, IgG2, IgG3, IgG4; IgA1 and IgA2). The class refers to the functions triggered by the antibody (also known as effector functions), in addition to some other structural features. Antibodies from different classes also differ in where they are released in the body and at what stage of an immune response. Importantly, while classes and subclasses of antibodies may be shared between species (at least in name), their functions and distribution throughout the body may be different. For example, mouse IgG1 is closer to human IgG2 than human IgG1 in terms of its function. The term humoral immunity is often treated as synonymous with the antibody response, describing the function of the immune system that exists in the body's humors (fluids) in the form of soluble proteins, as distinct from cell-mediated immunity, which generally describes the responses of T cells (especially cytotoxic T cells). In general, antibodies are considered part of the adaptive immune system, though this classification can become complicated. For example, natural IgM, which are made by B-1 lineage cells that have properties more similar to innate immune cells than adaptive, refers to IgM antibodies made independently of an immune response that demonstrate polyreactivity- they recognize multiple distinct (unrelated) antigens. These can work with the complement system in the earliest phases of an immune response to help facilitate clearance of the offending antigen and delivery of the resulting immune complexes to the lymph nodes or spleen for initiation of an immune response. Hence in this capacity, the function of antibodies is more akin to that of innate immunity than adaptive. Nonetheless, in general antibodies are regarded as part of the adaptive immune system because they demonstrate exceptional specificity (with some exception), are produced through genetic rearrangements (rather than being encoded directly in germline), and are a manifestation of immunological memory. In the course of an immune response, B cells can progressively differentiate into antibody-secreting cells (B cells themselves do not secrete antibody; B cells do, however, express B cell receptors, the membrane-bound form of the antibody, on their surface) or memory B cells. Antibody-secreting cells comprise plasmablasts and plasma cells, which differ mainly in the degree to which they secrete antibody, their lifespan, metabolic adaptations, and surface markers. Plasmablasts are rapidly proliferating, short-lived cells produced in the early phases of the immune response (classically described as arising extrafollicularly rather than from the germinal center) which have the potential to differentiate further into plasma cells. The literature is sloppy at times and often describes plasmablasts as just short-lived plasma cells- formally this is incorrect. Plasma cells, in contrast, do not divide (they are terminally differentiated), and rely on survival niches comprising specific cell types and cytokines to persist. Plasma cells will secrete huge quantities of antibody regardless of whether or not their cognate antigen is present, ensuring that antibody levels to the antigen in question do not fall to 0, provided the plasma cell stays alive. The rate of antibody secretion, however, can be regulated, for example, by the presence of adjuvant molecules that stimulate the immune response such as TLR ligands. Long-lived plasma cells can live for potentially the entire lifetime of the organism. Classically, the survival niches that house long-lived plasma cells reside in the bone marrow, though it cannot be assumed that any given plasma cell in the bone marrow will be long-lived. However, other work indicates that survival niches can readily be established within the mucosal tissues- though the classes of antibodies involved show a different hierarchy from those in the bone marrow. B cells can also differentiate into memory B cells which can persist for decades similarly to long-lived plasma cells. These cells can be rapidly recalled in a secondary immune response, undergoing class switching, affinity maturation, and differentiating into antibody-secreting cells. Antibodies are central to the immune protection elicited by most vaccines and infections (although other components of the immune system certainly participate and for some diseases are considerably more important than antibodies in generating an immune response, e.g. herpes zoster). Durable protection from infections caused by a given microbe – that is, the ability of the microbe to enter the body and begin to replicate (not necessarily to cause disease) – depends on sustained production of large quantities of antibodies, meaning that effective vaccines ideally elicit persistent high levels of antibody, which relies on long-lived plasma cells. At the same time, many microbes of medical importance have the ability to mutate to escape antibodies elicited by prior infections, and long-lived plasma cells cannot undergo affinity maturation or class switching. This is compensated for through memory B cells: novel variants of a microbe that still retain structural features of previously encountered antigens can elicit memory B cell responses that adapt to those changes. It has been suggested that long-lived plasma cells secrete B cell receptors with higher affinity than those on the surfaces of memory B cells, but findings are not entirely consistent on this point. (Source: Wikipedia, the free encyclopedia, see http://en.wikipedia.org/wiki/Antibody)

Note: The extraction of the abstract from the Wikipedia page may sometimes yield imperfect results. We are improving the algorithm regularly.

is rdfs:domain of gr:category gr:color gr:condition gr:depth gr:hasEAN_UCC-13 gr:hasGTIN-14 gr:hasMPN gr:hasManufacturer gr:hasStockKeepingUnit gr:height gr:isAccessoryOrSparePartFor gr:isConsumableFor gr:isSimilarTo gr:weight gr:width
is rdfs:range of gr:includes gr:isAccessoryOrSparePartFor gr:isConsumableFor gr:isSimilarTo

Note: This is a generic list. Some of the properties may not be applicable to this particular type of object.

Trademark Disclaimer:  Since this service returns class descriptions for potentiall any series of characters, it cannot indicate automatically whether a name is a registered trademark or otherwise protected. We assume no liability for the absence of trademark rights and other damages. See the section "License" below for details.

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Usage

The following shows how to model that you offer to sell [a/an/some] Antibody for $ 19.99.

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Microdata / Use with http://schema.org/Product

One of the most powerful usages of the class definitions from this site is to describe the type of your page and product for the schema.org product markup in Microdata syntax much more precisely.

Simply add the full URI of a class from this site, e.g. http://www.productontology.org/id/Antibody as an additional type as follows:

<div itemscope itemtype="http://schema.org/Product">
    <link itemprop="additionalType" href="http://www.productontology.org/id/Antibody" />
    <!-- other schema.org properties go in here -->
</div>		

Note: In HTML5, it is valid to use the <link> element in the body of a HTML document.

Here is a complete example:

<!DOCTYPE html>
<html>
<head>
    <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"/>
    <title>An offer to sell a / some Antibody</title>
</head>
<body>
<div itemscope itemtype="http://schema.org/Product" itemid="#product">
    <link itemprop="additionalType" href="http://www.productontology.org/id/Antibody" />
    <span itemprop="name">.. a short name for the object ...</span>
    Product description: 
    <span itemprop="description">... a longer description ...</span>
    <div itemprop="offers" itemscope itemtype="http://schema.org/Offer" itemid="#offer">
        <span itemprop="price">$19.99</span> 
        <link itemprop="availability" href="http://schema.org/InStock" />In stock
    </div>
</div>
</body>
</html>

Turtle Syntax

@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix pto: <http://www.productontology.org/id/> .
@prefix gr: <http://purl.org/goodrelations/v1#> .
@prefix foo: <http://example.com/> .

# The object
foo:myObject a <http://www.productontology.org/id/Antibody> ;
	a gr:SomeItems ;
	gr:name "... a short name for the object ..."@en ;
	gr:description "... a longer description ..."@en .

# The agent (person or company) who is offering it
foo:ACMECorp a gr:BusinessEntity ;
	gr:legalName "ACME Corp" ;
	gr:offers foo:Offer .
		
# The offer to sell it
foo:Offer a gr:Offering ;
	gr:includes foo:myObject;
	foaf:page <http://URI_of_the_page_containing_the_offer.com>;
	gr:hasBusinessFunction gr:Sell ;
	gr:validFrom "2011-01-24T00:00:00+01:00"^^xsd:dateTime ;
	gr:validThrough "2011-12-24T00:00:00+01:00"^^xsd:dateTime ;
	gr:hasPriceSpecification
         [ a gr:UnitPriceSpecification ;
           gr:hasCurrency "USD"^^xsd:string ;
           gr:hasCurrencyValue "19.99"^^xsd:float ;
           gr:validThrough "2011-12-24T00:00:00+01:00"^^xsd:dateTime ] .

Note: Replace gr:SomeItems (http://purl.org/goodrelations/v1#SomeItems) by gr:Individual if you are describing a unique object of that kind (e.g. antique furniture).

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RDFa

<!DOCTYPE html>
<html version="HTML+RDFa 1.1" xmlns="http://www.w3.org/1999/xhtml">
<head>
    <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"/>
    <title>An offer to sell a / some Antibody</title>
</head>
<body>
<div xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:gr="http://purl.org/goodrelations/v1#"
     xmlns:pto="http://www.productontology.org/id/"
     xmlns:foo="http://example.com/"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#">

<!-- The agent (person or company) who is offering it -->
   <div about="#ACMECorp" typeof="gr:BusinessEntity">
      <div property="gr:legalName">ACME Corp</div>
      <div rel="gr:offers">
<!-- The offer to sell it -->	
         <div about="#offer" typeof="gr:Offering">
            <div rel="gr:hasBusinessFunction" resource="http://purl.org/goodrelations/v1#Sell"></div>
            <div rel="gr:includes">
<!-- The object -->	
               <div about="#myObject" typeof="http://www.productontology.org/id/Antibody">
                  <div rel="rdf:type" resource="http://purl.org/goodrelations/v1#SomeItems"></div>
                  <div property="gr:description" xml:lang="en">... a longer description ...</div>
                  <div property="gr:name" xml:lang="en">.. a short name for the object ...</div>
               </div>
            </div>
            <div rel="foaf:page" resource="http://URI_of_the_page_containing_the_offer"></div>
            <div rel="gr:hasPriceSpecification">
               <div typeof="gr:UnitPriceSpecification">
                  <div property="gr:hasCurrency" content="USD" datatype="xsd:string">$ </div>
                  <div property="gr:hasCurrencyValue" datatype="xsd:float">19.99</div>
                  <div property="gr:validThrough" content="2011-12-24T00:00:00+01:00" 
					   datatype="xsd:dateTime"></div>
               </div>
            </div>
            <div property="gr:validFrom" content="2011-01-24T00:00:00+01:00"
                 datatype="xsd:dateTime"></div>
            <div property="gr:validThrough" content="2011-12-24T00:00:00+01:00"
                 datatype="xsd:dateTime"></div>
         </div>
      </div>
   </div>
</div>
</body>
</html>

Note: Replace gr:SomeItems (http://purl.org/goodrelations/v1#SomeItems) by gr:Individual if you are describing a unique object of that kind (e.g. antique furniture).

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RDF/XML

<?xml version="1.0" encoding="UTF-8" ?>
<rdf:RDF xmlns:gr="http://purl.org/goodrelations/v1#" 
  xmlns:pto="http://www.productontology.org/id/" 
  xmlns:xsd="http://www.w3.org/2001/XMLSchema#" 
  xmlns:foaf="http://xmlns.com/foaf/0.1/" 
  xmlns:foo="http://example.com/" 
  xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<!-- The object -->
  <rdf:Description rdf:about="http://example.com/myObject">
    <rdf:type rdf:resource="http://www.productontology.org/id/Antibody"/>    
    <rdf:type rdf:resource="http://purl.org/goodrelations/v1#SomeItems"/>
    <gr:name xml:lang="en">... a short name for the object ...</gr:name>
    <gr:description xml:lang="en">... a longer description ...</gr:description>
  </rdf:Description>
<!-- The agent (person or company) who is offering it -->
  <gr:BusinessEntity rdf:about="http://example.com/ACMECorp">
    <gr:legalName>ACME Corp</gr:legalName>
    <gr:offers rdf:resource="http://example.com/Offer" />
  </gr:BusinessEntity>
<!-- The offer to sell it -->   
  <gr:Offering rdf:about="http://example.com/Offer">
    <gr:includes rdf:resource="http://example.com/myObject" />
    <foaf:page rdf:resource="http://URI_of_the_page_containing_the_offer"/>
    <gr:hasBusinessFunction rdf:resource="http://purl.org/goodrelations/v1#Sell"/>
    <gr:validFrom rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">
      2011-01-24T00:00:00+01:00</gr:validFrom>
    <gr:validThrough rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">
      2011-12-24T00:00:00+01:00</gr:validThrough>
    <gr:hasPriceSpecification>
      <gr:UnitPriceSpecification>
        <gr:hasCurrency rdf:datatype="http://www.w3.org/2001/XMLSchema#string">USD</gr:hasCurrency>
        <gr:hasCurrencyValue rdf:datatype="http://www.w3.org/2001/XMLSchema#float">19.99</gr:hasCurrencyValue>
        <gr:validThrough rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">
          2011-12-24T00:00:00+01:00</gr:validThrough>
      </gr:UnitPriceSpecification>
    </gr:hasPriceSpecification>
  </gr:Offering>

</rdf:RDF>

Note: Replace gr:SomeItems (http://purl.org/goodrelations/v1#SomeItems) by gr:Individual if you are describing a unique object of that kind (e.g. antique furniture).

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SPARQL Query

prefix foaf: <http://xmlns.com/foaf/0.1/> 
prefix xsd: <http://www.w3.org/2001/XMLSchema#> 
prefix pto: <http://www.productontology.org/id/> 
prefix gr: <http://purl.org/goodrelations/v1#> 
prefix foo: <http://example.com/> 

# Find the cheapest offer for a Antibody

SELECT * WHERE{
?company gr:offers ?offer .
?offer a gr:Offering .
?offer gr:hasBusinessFunction gr:Sell .
OPTIONAL {?offer rdfs:label ?label } .
OPTIONAL {?offer gr:name ?label } .
OPTIONAL {?offer rdfs:comment ?label } .
OPTIONAL {?offer gr:description ?label } .
?offer gr:hasPriceSpecification ?p .
?p a gr:UnitPriceSpecification .
?p gr:hasCurrency ?currency .
?p gr:hasCurrencyValue ?price .
?offer gr:includes ?product .
?product a <http://www.productontology.org/id/Antibody> .
}
ORDER BY (?price)
LIMIT 10

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Facebook Open Graph Protocol

You can also use the class definitions from this site for better describing the type of your page or product for the Facebook Open Graph Protocol.

Simply define the namespace prefix pto: in the <html> element of your page

<html version="HTML+RDFa 1.1" 
	xmlns="http://www.w3.org/1999/xhtml" 
	xmlns:pto="http://www.productontology.org/id/" 
	>

and use the compact URI (CURIE) pto:Antibody in combination with og:type as follows:

	<meta property="og:type" content="pto:Antibody"/>

A complete example is here.

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Contact Information

Univ.-Prof. Dr. Martin Hepp

E-Business and Web Science Research Group
Chair of General Management and E-Business
Universität der Bundeswehr München
Werner-Heisenberg-Weg 39
D-85579 Neubiberg, Germany

Phone: +49 89 6004-4217
eMail: mhepp(at)computer.org (preferred mode of communication)
Web: http://www.heppnetz.de/
Web: http://www.unibw.de/ebusiness/

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Caching Policy

In order to minimize the load on the Wikipedia API, all requests are cached internally for 72 hours. This means that changes to the English Wikipedia will be available in this service within 72 hours or less if the same entry has been requested before. Classes not requested within the last six hours are always guaranteed to be in sync with the latest version in Wikipedia.

The RDF/XML dump file is updated every 12 hours only.

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License

The class definition text is taken from Wikipedia, the free encyclopedia under a Creative Commons Attribution-ShareAlike 3.0 Unported (CC BY-SA 3.0) license. Accordingly, the ontology class definitions are available under the very same license.

Trademark Disclaimer:  Since this service returns class descriptions for potentially any series of characters, it cannot indicate automatically whether a name is a registered trademark or otherwise protected. If you want us to block a certain name, please send your request including proof of your rights on the name to our contact address listed below.. Any of the trademarks, service marks, collective marks, design rights or similar rights that are mentioned, used, or cited in this service are the property of their respective owners. Their use here does not imply that you may use them for any purpose other than for the same or a similar informational use as contemplated by the original authors of the underlying Wikipedia articles under the CC-BY-SA and GFDL licensing schemes. Productontology.org is neither endorsed by nor affiliated with any of the holders of any such rights and as such cannot grant any rights to use any otherwise protected materials. Your use of any such or similar incorporeal property is at your own risk.

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Acknowledgements

Thanks to Stefano Bertolo, Julien Chaumond, Bob Ferris, Kingsley Idehen, Axel Polleres, Andreas Radinger, Alex Stolz, and Giovanni Tummarello for very valuable feedback, and to Katharina Siorpaes and Daniel Bachlechner, who contributed to the initial analysis of the stability of Wikipedia URIs back in 2007.

The work on The Product Types Ontology has been supported by the German Federal Ministry of Research (BMBF) by a grant under the KMU Innovativ program as part of the Intelligent Match project (FKZ 01IS10022B).

BMBF logo

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References

Wikipedia: Antibody, available at http://en.wikipedia.org/wiki/Antibody.

Hepp, Martin: GoodRelations: An Ontology for Describing Products and Services Offers on the Web, Proceedings of the 16th International Conference on Knowledge Engineering and Knowledge Management (EKAW2008), Acitrezza, Italy, September 29 - October 3, 2008, Springer LNCS, Vol 5268, pp. 332-347.

Hepp, Martin; Siorpaes, Katharina; Bachlechner, Daniel: Harvesting Wiki Consensus: Using Wikipedia Entries as Vocabulary for Knowledge Management, IEEE Internet Computing, Vol. 11, No. 5, pp. 54-65, Sept-Oct 2007.

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